Excel Hospital
  • What is Pseudo Membranous Colitis?

    • Pseudo membranous colitis is inflammation of the colon that occurs in some people who have taken antibiotics.
    • Pseudo membranous colitis is sometimes called antibiotic-associated colitis or C. difficile colitis.
    • The inflammation in pseudo membranous colitis is almost always associated with an overgrowth of the bacterium Clostridium difficile.
    • Sometimes Pseudo membranous colitis can be life-threatening.

  • Causes

    • Antibiotics use
    • Staying in the hospital or a nursing home
    • Increasing age over 65 years
    • Weakened immune system
    • Colon diseases, such as inflammatory bowel disease or colorectal cancer
    • Intestinal surgery
    • Chemotherapy
    • History of pseudo membranous colitis

  • Symptoms

    • Diarrhoea - watery/bloody
    • Pus or mucus in stool
    • Abdominal cramps and pain
    • Fever
    • Nausea/Vomit
    • Dehydration

  • Complications

    • Hypokalemia
    • Hypotension
    • Recurrence of pseudo membranous colitis, days or even weeks after initial treatment
    • Kidney failure, due to severe dehydration
    • Perforated Colon
    • Toxic mega colon

  • Diagnosis

    • Stool sample
    • Blood tests
    • X Ray
    • Colonoscopy
    • CT Scan

  • Treatment

    Medical Management:
    • Stopping the Antibiotic (whenever possible)
    • Oral - Metronidazole, Vancomycin
    • Treating recurring signs and symptoms

    Surgery : Generally in case of Complication (e.g. Rupture of the colon, inflammation of the lining of the abdominal wall-peritonitis).

    Preventing recurrences : Pro biotic treatment